Stromal stem cells as an innovative therapy in the treatment of neonatal bronchopulmonary dysplasia: literature review.
Keywords:
Displasia broncopulmonar, Células madre estromales, neonatos, prematuros extremosAbstract
Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting neonates, especially those with extremely low birth weight. This review explores the potential of stromal stem cells (ESCs) in the treatment of BPD, analyzing preclinical and clinical studies highlighting their efficacy and mechanisms of action. A literature review was performed in scientific databases such as Proquest, Scopus, Springer, Web of Science, Google Scholar, selecting studies between 2018 and 2024. Preclinical and clinical research on the use of stromal stem cells for the treatment of bronchopulmonary dysplasia were included. The results show that the patients who benefit most from mesenchymal stem cell (MSCs) treatment for bronchopulmonary dysplasia (BPD) are mainly extremely preterm infants, with early administration showing more favorable results. It is concluded that although multiple benefits have been shown in animal trials, further clinical studies are still needed in order to optimize treatment protocols, especially in terms of dosage and choice of route of administration.
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