Innovation in tissue engineering for post-infarction cardiac restoration
Keywords:
Tissue engineering, Myocardial infarction, Cardiac regenerationAbstract
Tissue engineering presents itself as an innovative approach to restore cardiac tissue after a myocardial infarction, combining engineering, biology, and medicine. The integration of biomaterials, stem cells, and biochemical factors aims to promote cardiac regeneration and enhance functional recovery. Cardiovascular diseases are the leading cause of mortality globally, and myocardial infarction is a serious public health issue in Ecuador, with over 36,000 deaths recorded between 2019 and 2021. The objective of this research work is to analyze the impact of biomaterials used in tissue engineering for the restoration of the myocardium after an infarction, focusing on their biocompatibility and ability to facilitate tissue regeneration by examining the role of stem cells. A qualitative systematic review was conducted, utilizing documentary techniques through a bibliographic review of scientific articles and publications related to literature in cardiology, medicine, and tissue engineering. The study contributes to cardiac tissue repair and its integration into tissue engineering matrices while identifying challenges and opportunities that could improve outcomes for patients with myocardial infarction. Applications such as bioengineered cardiac patches are highlighted, providing mechanical support and promoting angiogenesis. Understanding the pathophysiology of infarction and designing innovative strategies are crucial for improving cardiovascular health and the quality of life for patients.
Downloads
References
Arslan, F., Lai, R. C., Smeets, M. B., Akeroyd, L., Choo, A., Aguor, E. N. E., et al. (2013). Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Research, 10(3), 301–312. http://doi.org/10.1016/j.scr.2013.01.002
Basara, G., Bahcecioglu, G., Ozcebe, S. G., Ellis, B. W., Ronan, G. & Zorlutuna, P. (2022). Myocardial infarction from a tissue engineering and regenerative medicine point of view: A comprehensive review on models and treatments. Biophysics Reviews, 3(3). https://doi.org/10.1063/5.0093399
Calero Moscoso, C. (2023). Diagnóstico y Tratamiento de la Enfermedad Cerebro Vascular Aguda Isquémica. Rev. CAMbios-HECAM, 22(2), 1-17. https://doi.org/10.36015/cambios.v22.n2.2023.929
Chachques, J. C., Herreros, J., Trainini, J. C., Lago, N., Díez-Solórzano, L., Tascón, V. y Genovese, J. (2011). Ingeniería tisular y miocardio bioartificial. Cirugía Cardiovascular, 18(3), 217-224. https://doi.org/10.1016/S1134-0096(11)70057-2
Chen, C. H., Chang, M. Y., Wang, S. S. y Hsieh, P. C. (2014). Injection of autologous bone marrow cells in hyaluronan hydrogel improves cardiac performance after infarction in pigs. American Journal of Physiology - Heart and Circulatory Physiology, 306(7), H1078–H1086. https://doi.org/10.1152/ajpheart.00801.2013
Choi, Y. C., Choi, J. S., Kim, B. S., Kim, J. D., Yoon, H. I. y Cho, Y. W. (2012). Decellularized extracellular matrix derived from porcine adipose tissue as a xenogeneic biomaterial for tissue engineering. Tissue Eng Part C Methods, 18(11), 866-876. https://pubmed.ncbi.nlm.nih.gov/22559904/
Coronel, K. y Núñez, L. (2022). Aplicación de la ingeniería de tejidos en el desarrollo de válvulas cardiacas y miocardio. [Tesis de pregrado, Universidad Técnica de Ambato]https://repositorio.uta.edu.ec/bitstream/123456789/34966/1/BQ%20307.pdf
Espinosa-Yépez, K. R. y García-Cevallos, M. P. (2023). Infarto agudo de miocardio en Ecuador: carga de la enfermedad y distribución geográfica. Revista MetroCiencia, 32(3), 20-7. https://doi.org/10.47464/MetroCiencia/vol31/3/2023/18-27
García Muñoz, F., Crespo Ferrer, P. V. y García López, J. M. (2013). Ingeniería tisular cardiaca. Actualidad Médica, 98(789), 101-105. https://digibug.ugr.es/handle/10481/36353?show=full
Gunata, M. y Parlakpinar, H. (2021). A review of myocardial ischaemia/reperfusion injury: pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment. Cell biochemistry and function, 39(2),190-217. https://10.1002/cbf.3587
Instituto Nacional de Estadísticas y Censos (2023). 01 N°-01-2023-ECEH Registro Estadístico de camas y egresos hospitalarios. Dirección de Estadísticas Sociodemográficas. https://www.ecuadorencifras.gob.ec/documentos/web-inec/Estadisticas_Sociales/Camas_Egresos_Hospitalarios/Cam_Egre_Hos_2022/Boletin_tecnico_ECEH_2022.pdf
Katili, P.A., Karima, A.P., Azwani, W. et al. (2023). Application of Human Induced Pluripotent Stem Cells for Tissue Engineered Cardiomyocyte Modelling. Regen. Eng. Transl. Med, 9, 431–446. https://doi.org/10.1007/s40883-023-00294-1
Kitsuka, T., Takahashi, F., Reinhardt, J., Watanabe, T., Ulziibayar, A., Yimit, A., Kelly, J. y Shinoka, T. (2022). Advances in Cardiac Tissue Engineering. Rev. Bioengineering, 9(11). 696. https://doi.org/10.3390/bioengineering9110696
Kleindorfer, D. O., Towfighi, A., Chaturvedi, S., Cockroft, K.M., Gutierrez, J., Lombardi-Hill, D., Kamel, H., Kernan, W.N., Kittner, S.J.,
Leira, E.C., Lennon, O., Meschia, J. F., Nguyen, T.N., Pollak, P. M., Santangeli, P., Sharrief, A. Z., Smith, Tanya N. Turan, T. D., Williams, L. S. (2021). 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. AHA/ASA Guideline Stroke, 52(7). https://doi.org/10.1161/STR.0000000000000375
Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A. y Chen, T. S. (2010). Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Research, 4(3), 214-222. http://doi.org/10.1016/j.scr.2009.12.003
Lee, A., Hudson, A. R., Shiwarski, D. J., Tashman, J. W., Hinton, T. J., Yerneni, S., Bliley, J. M., Campbell, P. G. y Feinberg, A. W. (2019). 3D bioprinting of collagen to rebuild components of the human heart. Science, 365, 482–487. https://doi.org/10.1126/science.aav9051
Li, M., Wu, H., Yuan, Y., Hu, B. y Gu, N. (2021). Recent fabrications and applications of cardiac patch in myocardial infarction treatment. Rev. View, 03, 20200153. https://10.1002/VIW.20200153
Li, Z. y Guan, J. (2011). Hydrogels for cardiac tissue engineering. Polymers, 3(2), 740-761. https://doi.org/10.3390/polym3020740
Lopez-Jaramilo, P. & Lopez-Lopez J. (2022). Factores de riesgo y muerte cardiovascular en América del Sur. Rev. Clínica e Investigacion en arteriosclerosis, 35(4). 195-200. 10.1016/j.arteri.2022.12.001
Lunkenheimer, P. P., Redmann, K., Westermann, P., Rothaus, K., Cryer, C. W., Niederer, P. et al. (2006). The myocardium and its fibrous matrix working in concert as a spatially netted mesh: A critical review of the purported tertiary structure of the ventricular mass. European Journal of
Cardio-Thoracic Surgery, 29(Suppl 1), S41-S49.
Maiullari, F., Costantini, M., Milan, M., Pace, V., Chirivi, M., Maiullari, S., Rainer, A., Baci, D., Marei, H. E., Seliktar, D. (2018). A multi-cellular 3D bioprinting approach for vascularized heart tissue engineering based on HUVECs and iPSC-derived cardiomyocytes. Scientific Reports, 8, 13532. https://doi.org/10.1038/s41598-018-31848-x
Miyahara, Y., Nagaya, N., Kataoka, M., Yanagawa, B., Tanaka, K., Hao, H., Ishino, K., Ishida, H., Shimizu, T., Kangawa, K., Sano, S., Okano, T.,
Kitamura, S., y Mori, H. (2006). Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nature Medicine, 12(4), 459-465. https://doi.org/10.1038/nm1390
Organización Mundial de la Salud (OMS, 2024). Enfermedades cardiovasculares. https://www.who.int/es/health-topics/cardiovascular-diseases#tab=tab_2
Organización Panamericana de Salud (OPS, 2021). La carga de las enfermedades cardiovasculares en la Región de las Américas, 2000-2019. Portal de Datos de NMH. https://www.paho.org/es/enlace/carga-enfermedades-cardiovasculares
Pomeroy, J. E., Helfer, A. & Bursac, N. (2020). Biomaterializing the promise of cardiac tissue engineering. Rev. Biotechnology advances, 42. 107353. 10.1016/j.biotechadv.2019.02.009
Roacho-Pérez, J. A., Garza-Treviño, E. N., Moncada-Saucedo, N. K., Carriquiry-Chequer, P. A., Valencia-Gómez, L. E., Matthews, E. R., Gómez-Flores, V., Simental-Mendía, M., Delgado-Gonzalez, P., Delgado-Gallegos, J. L. et al. (2022). Artificial Scaffolds in Cardiac Tissue Engineering. Rev. Life, 12, 1117. https://doi.org/10.3390/life12081117
Roshanbinfar, K., Esser, T. U. & Engel, F. B. (2021). Stem cells and their cardiac derivatives for cardiac tissue engineering and regenerative medicine. Antioxidants & Redox Signaling, 35(3), 143-162. https://doi.org/10.1089/ars.2020.819
Scafa Udriște, A., Niculescu, A. G., Iliuță, L., Bajeu, T., Georgescu, A., Grumezescu, A. M. & Bădilă, E. (2023). Progress in biomaterials for cardiac tissue engineering and regeneration. Polymers, 15(5), 1177. https://doi.org/10.3390/polym15051177
Schirone, L., Forte, M., D’Ambrosio, L., Valenti, V., Vecchio, D., Schiavon, S., ... & Sciarretta, S. (2022). An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives. Cells, 11(7), 1165. https://doi.org/10.3390/cells11071165
Sharma, V., Dash, S. K., Govarthanan, K., Gahtori, R., Negi, N., Barani, M., ... & Ojha, S. (2021). Recent advances in cardiac tissue engineering for the management of myocardium infarction. Cells, 10(10), 2538. https://10.1002/smll.202003765
Stevens, K. R., Kreutziger, K. L., Dupras, S. K., Korte, F. S., Regnier, M., y Muskheli, V. (2009). Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue. Proceedings of the National Academy of Sciences of the United States of America, 106(39), 16568-16573. https://doi.org/10.1073/pnas.0903543106
Tariq, U., Gupta, M., Pathak, S., Patil, R., Dohare, A. & Misra, S. K. (2022). Role of biomaterials in cardiac repair and regeneration: therapeutic intervention for myocardial infarction. ACS Biomaterials Science & Engineering, 8(8), 3271-98. https://doi.org/10.1021/acsbiomaterials.2c00454
The European Society of Cardiology (2023). Guía ESC 2023 sobre el diagnóstico y tratamiento de síndromes coronarios agudos. https://secardiologia.es/images/2024/Gu%C3%ADas/Gui%CC%81a_ESC_2023_sobre_SCA.pdf
Trombino, S., Curcio, F., Cassano, R., Curcio, M., Cirillo, G. & Iemma, F. (2021). Polymeric biomaterials for the treatment of cardiac post-infarction injuries. Pharmaceutics, 13(7), 1038. https://doi.org/10.3390/pharmaceutics13071038
Tsao, C., Aday, A., Almarzooq, Z., Alonso, A., Beaton, A., Bittencourt, M., Boehme, A., Buxton, A., Carson, A., Commodore-Mensah, Y., Elkind, M., Evenson, K., Eze-Nliam, C., Ferguson, J., Generoso, G., Ho ,J., Kalani, R., Khan, S., Kissela, B., Knutson, K., Levine, D., Lewis, T., Liu, J., Loop, M., Ma, J., Mussolino, M., Navaneethan, S., Perak, A., Poudel, R., Rezk-Hanna, M., Roth, G., Schroeder, E., Shah, S., Thacker, E.,
VanWagner, L., Virani, S., Voecks, J., Wang, N., Yaffe, K., Martin, S.; Comité de Estadísticas de Prevención y el Subcomité de Estadísticas de
Ataque o Derrame Cerebral de la American Heart Association(American Heart Association (2022). Actualización de estadísticas sobre enfermedades cardiovasculares. Un informe de la American Heart Association. https://doi:10.1161/CIR.0000000000001052
Valikeserlis, I., Athanasiou, A. A. & Stakos, D. (2021). Cellular mechanisms and pathways in myocardial reperfusion injury. Rev. Coronary Artery Disease, 32(6), 567-77. https://10.1097/MCA.0000000000000997
Wang, F. y Guan, J. (2010). Cellular cardiomyoplasty and cardiac tissue engineering for myocardial therapy. Advanced Drug Delivery Reviews, 62(7-8), 784-797. https://doi.org/10.1016/j.addr.2010.03.006
Wang, L., Serpooshan, V. y Zhang, J. (2021) Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling. Frontiers in Cardiovascular Medicine, (8). https://10.3389/fcvm.2021.621781
Waters, R., Alam, P., Pacelli, S., Chakravarti, A. R., Ahmed, R. P. H. y Paul, A. (2018). Stem cell-inspired secretome-rich injectable hydrogel to repair injured cardiac tissue. Acta Biomaterialia, 69, 95–106. https://doi.org/10.1016/j.actbio.2017.12.025
Yi, B. A., Wernet, O., y Chien, K. R. (2010). Pregenerative medicine: Developmental paradigms in the biology of cardiovascular regeneration. The Journal of Clinical Investigation, 120(1), 20-28. https://doi.org/10.1172/JCI41263
Yu, D., Wang, X., & Ye, L. (2021). Cardiac tissue engineering for the treatment of myocardial infarction. Journal of Cardiovascular Development and Disease, 8(11), 153. https://doi.org/10.3390/jcdd8110153
Yu, D., Wang, X. y Ye, L. (2021). Cardiac Tissue Engineering for the Treatment of Myocardial Infarction. Journal of cardiovascular development and disease, 8(11), 153. https://doi.org/10.3390/jcdd8110153
Yukitaka, I., Toru, U., Yoshihiro, Y., Shogo, T., Hidekazu, N., Takashi, K., Manabu, S., Koichi, T., Toshiaki, F., Mamoru, T. & Haruhiko, K. (2024). Technique for Recanalization of Sheath Introducer Occlusion due to Captured Thrombus during Mechanical Thrombectomy for Acute Ischemic
Stroke: A Technical Note. Journal of Neuroendovascular Therapy, 18(5), (149-154). https://doi.org/10.5797/jnet.tn.2023-0099
Published
Issue
Section
License
Copyright (c) 2025 Opuntia Brava
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.png)
.png)
